|
KMID : 0043320170400010025
|
|
Archives of Pharmacal Research
2017 Volume.40 No. 1 p.25 ~ p.31
|
|
|
Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08
|
|
Kong Fan Dong
Zhou Li Man
Ma Qing Yun
Huang Sheng Zhuo
Wang Pei
Dai Hao Fu
Zhao You Xing
|
|
|
Abstract
|
|
|
|
Three new compounds named penicitor A, aculene E and penicitor B, as well as four known compounds, were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with a marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mosher’s method, CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2?7 showed quorum sensing inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.
|
|
|
KEYWORD
|
|
|
Marine fungus, Metabolites, Penicillium sp., Quorum sensing inhibitory activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|